The Marians laboratory’s long-standing interests have been in the nature of replication fork operations, the mechanisms of replication fork restart, and the results of collisions between the replication fork and transcription complexes and R-loops. Our approach is centered on biochemical reconstitution experiments using purified proteins and specialized templates to model these processes. We have recently shifted our primary focus from using bacterial proteins to using human proteins to develop these in vitro systems. Postdoctoral positions are available for appropriately trained, creative individuals who are interested in how human replication acts both as a genome stabilizer and, when corrupted, as a genome destabilizer. Extensive biochemical training is a must. Familiarity with mammalian overexpression systems is a plus.

The laboratory is part of an exceptionally strong group of researchers investigating diverse aspects of genome integrity in the Molecular Biology Program of Memorial Sloan Kettering Cancer Center (https://www.mskcc.org/research-areas/programs-centers/molecular-biology).

MSKCC is a top-ranked comprehensive cancer center located on the Upper East Side of Manhattan in New York City. MSKCC is committed to the training and career development of its postdoctoral researchers (https://www.mskcc.org/education-training/postdoctoral). The wider community includes Weill Cornell Medical College and Rockefeller University and offers additional training and opportunities for scientific interaction.

To learn more about Postdoc compensation and benefits at MSK, please visit  https://www.mskcc.org/education-training/postdoctoral/resources-postdocs/compensation-benefits-resources

Interested parties should submit applications to Kenneth Marians at [email protected] and copying at [email protected].