Chemical Biology Program

The Yueming Li Lab

Yueming Li, PhD

Professor

Research Interests

Basic & Translational research in Cancer and Alzheimer’s disease:
From disease mechanism to therapeutic development.

Research Areas

Target Identification & Drug Discovery
Chemical Biology & Medicinal Chemistry
Biochemistry & Enzymology
Biophysics & Structural Biology
Animal models & Behavior
Neurobiology & Neuroinflammation
Autophagy, Protein Aggregation & Clearance

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Research Projects

Research Projects

Featured News

At Work: Biochemist Yueming Li

Yueming Li aims to develop new agents that inhibit particular intramembrane proteases associated with cancer.

Article

An illustration of a beta-amyloid plaque among the neurons in a brain.

MSK Study Links Inflammation to Alzheimer’s Disease Development

An enzyme that contributes to plaque formation in the brain also serves as a first line of defense against bacteria and viruses, suggesting a link between the two.

Nanotechnology May Aid Diagnosis

Biochemist Yueming Li commented on new technology that is three million times more sensitive at detecting Alzheimer's disease and certain cancers....

Publications Highlights

Nie P, Kalidindi T, Nagle VL, et al. Imaging of Cancer γ-Secretase Activity Using an Inhibitor-Based PET Probe. Clin Cancer Res. 2021;27(22):6145-6155. doi:10.1158/1078-0432.CCR-21-0940

Hur, J.-Y., Frost, G. R., Wu, X., Crump, C., Pan, S. J., Wong, E., … Li, Y.-M. (2020). The innate immunity protein IFITM3 modulates γ-secretase in Alzheimer’s disease. Nature. doi:10.1038/s41586-020-2681-2

Mekala, S., Nelson, G., & Li, Y.-M. Recent developments of small molecule γ-secretase modulators for Alzheimer’s disease. RSC Medicinal Chemistry, 11(9), 1003-1022. doi:10.1039/D0MD00196A (2020)

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People

Yueming Li, PhD

Professor

Dr. Yueming Li studies disease mechanism of Cancer and Alzheimer’s, with the goal of developing novel therapeutics for clinical use.
PhD, University of California Berkeley

[email protected]: Email Address
646-888-2194 or 2193: Office Phone

Members

Pascale M. Presendor
Administrative Assistant

Pictured: Ji Yeun Hur — Ji Yeun Hur
Senior Research Scientist

Lab Alumni

Xianzhong Wu, MD, Laboratory Manager — Xianzhong Wu
Laboratory Manager

Qi Liu

Research Fellow

David Schachter, Graduate Student — David Schachter
Graduate Student

Courtney Alexander, BS — Courtney Alexander
Graduate Student

Deming Chau, PhD — Deming Chau
Postdoctoral Fellow

Jennifer Chien, PhD — Jennifer Chien
Postdoctoral Fellow

Christina J. Crump, BS — Christina J. Crump
Graduate Student

Kelly (Yunke) Guo

Graduate Student

Manish Malviya
Senior Research Scientist

Wenbo Pei

Xiaojun Lei

Graduate Student

Yuan Tian

Graduate Student

Lisa Placanica

Graduate Student

Kwangwook Ahn, PhD — Kwangwook Ahn
Research Fellow

C. Chad Shelton

Graduate Student

Lane M. Gilchrist

Sabbatical Professor

Haige Lu, PhD — Haige Lu
Research Fellow

Bhramdeo Bassit

Research Technician

Lei Zhu

Research Fellow

Leonid Tarassishin

Research Fellow

Jiong Chun

Research Fellow

Ingrid Ye Yin

Research Fellow

Lab Affiliations

Open Positions

To learn more about available postdoctoral opportunities, please visit our Career Center

To learn more about compensation and benefits for postdoctoral researchers at MSK, please visit Resources for Postdocs

Career Opportunities

Apply now

Get in Touch

[email protected]

Lab Head Email
646-888-2194 or 2193

Office Phone
646-422-0640

Office Fax
646-888-2204 or 2531

Lab Phone

Disclosures

Doctors and faculty members often work with pharmaceutical, device, biotechnology, and life sciences companies, and other organizations outside of MSK, to find safe and effective cancer treatments, to improve patient care, and to educate the health care community.

MSK requires doctors and faculty members to report (“disclose”) the relationships and financial interests they have with external entities. As a commitment to transparency with our community, we make that information available to the public.

Yueming Li discloses the following relationships and financial interests:

BrightFocus Foundation
Professional Services and Activities
Cure Alzheimer's Fund
Professional Services and Activities

Jiangsu Continental Medical Development Co
Intellectual Property Rights

The information published here is a complement to other publicly reported data and is for a specific annual disclosure period. There may be differences between information on this and other public sites as a result of different reporting periods and/or the various ways relationships and financial interests are categorized by organizations that publish such data.

This page and data include information for a specific MSK annual disclosure period (January 1, 2023 through disclosure submission in spring 2024). This data reflects interests that may or may not still exist. This data is updated annually.

Learn more about MSK’s COI policies here. For questions regarding MSK’s COI-related policies and procedures, email MSK’s Compliance Office at [email protected].

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