Nie P, Kalidindi T, Nagle VL, et al. Imaging of Cancer γ-Secretase Activity Using an Inhibitor-Based PET Probe. Clin Cancer Res. 2021;27(22):6145-6155. doi:10.1158/1078-0432.CCR-21-0940
Hur, J.-Y., Frost, G. R., Wu, X., Crump, C., Pan, S. J., Wong, E., … Li, Y.-M. (2020). The innate immunity protein IFITM3 modulates γ-secretase in Alzheimer’s disease. Nature. doi:10.1038/s41586-020-2681-2
Wong, E., Liao, G. P., Chang, J. C., Xu, P., Li, Y. M., & Greengard, P. (2019). GSAP modulates γ-secretase specificity by inducing conformational change in PS1. Proc Natl Acad Sci U S A, 116(13), 6385-6390. doi:10.1073/pnas.1820160116
Gertsik, N., Am Ende, C.W., Geoghegan, K.F., Nguyen, C., Mukherjee, P., Mente, S., Seneviratne, U., Johnson, D.S. & Li, Y.M. Mapping the Binding Site of BMS-708163 on gamma-Secretase with Cleavable Photoprobes. Cell chemical biology 24, 3-8 (2017).
Gilchrist, M.L., Ahn, K. & Li, Y.M. Imaging and Functional Analysis of gamma-Secretase and Substrate in a Proteolipobead System with an Activity-Based Probe. Analytical chemistry 88, 1303-1311 (2016).
Crump, C.J., Murrey, H.E., Ballard, T.E., Am Ende, C.W., Wu, X., Gertsik, N., Johnson, D.S. & Li, Y.M. Development of Sulfonamide Photoaffinity Inhibitors for Probing Cellular gamma-Secretase. ACS Chem Neurosci 7, 1166-1173 (2016).
Paresi, C. J., Liu, Q. & Li, Y. M. Benzimidazole covalent probes and the gastric H(+)/K(+)-ATPase as a model system for protein labeling in a copper-free setting. Mol Biosyst 12, 1772-1780, doi:10.1039/c6mb00024j (2016).
Gertsik, N., Chau, D.M. & Li, Y.M. gamma-Secretase Inhibitors and Modulators Induce Distinct Conformational Changes in the Active Sites of gamma-Secretase and Signal Peptide Peptidase. ACS chemical biology 10, 1925-1931 (2015).
Villa, J.C., Chiu, D., Brandes, A.H., Escorcia, F.E., Villa, C.H., Maguire, W.F., Hu, C.J., de Stanchina, E., Simon, M.C., Sisodia, S.S., Scheinberg, D.A. & Li, Y.M. Nontranscriptional role of Hif-1alpha in activation of gamma-secretase and notch signaling in breast cancer. Cell Rep 8, 1077-1092 (2014).
Review Articles
Hur, JY. γ-Secretase in Alzheimer’s disease. Exp Mol Med (2022).https://doi.org/10.1038/s12276-022-00754-8
Jonas Lauren A., Jain Tanya and Li Yue-Ming 2022Functional insight into LOAD-associated microglial response genes Open Biol.12210280210280
Luo, J.E., Li, YM. Turning the tide on Alzheimer’s disease: modulation of γ-secretase. Cell Biosci 12, 2 (2022). https://doi.org/10.1186/s13578-021-00738-7
Mekala, Shekar, Grady Nelson, and Yue-Ming Li. 2020. “Recent Developments of Small Molecule γ-Secretase Modulators for Alzheimer’s Disease.” RSC Medicinal Chemistry 11(9): 1003–22. http://dx.doi.org/10.1039/D0MD00196A
Wong, Eitan, Georgia R Frost, and Yue-Ming Li. 2020. “γ-Secretase Modulatory Proteins: The Guiding Hand Behind the Running Scissors .” Frontiers in Aging Neuroscience 12. https://www.frontiersin.org/article/10.3389/fnagi.2020.614690
Mekala, S., Nelson, G., & Li, Y.-M. Recent developments of small molecule γ-secretase modulators for Alzheimer’s disease. RSC Medicinal Chemistry, 11(9), 1003-1022. doi:10.1039/D0MD00196A (2020)
Frost GR, Jonas LA, Li YM. Friend, Foe or Both? Immune Activity in Alzheimer’s Disease. Front Aging Neurosci.11:337. doi: 10.3389/fnagi.2019.00337. PMID: 31920620; PMCID: PMC6916654. (2019)
Frost, G.R. & Li, Y.M. The role of astrocytes in amyloid production and Alzheimer’s disease. Open Biol 7 (2017).
Crump, C.J., Johnson, D.S. & Li, Y.M. Development and mechanism of gamma-secretase modulators for Alzheimer’s disease. Biochemistry 52, 3197-3216 (2013).