Nicholas F. Kuhn, PhD

Graduate Student

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Nicholas F. Kuhn, BS, MS, Graduate Student

Email

[email protected]

Dissertation

Engineering Chimeric Antigen Receptor (CAR) T Cells to Elicit an Endogenous Antitumor Immune Response (2019)

Mentor

Renier Brentjens

Start Year

2014

End Year

2019

Education

BS, Julius Maximilian University of Würzburg; MS, Charité University Medicine Berlin

Science is a universal language that challenges reason, logic, and creativity. I have always been intrigued by the system and order that are inherent to science. I saw a PhD as a great opportunity to develop my scientific and professional skills and meet like-minded people with different ideas. Gerstner Sloan Kettering belongs to a great cancer biology institution and offers small classes and a tight-knit community. The straightforward curriculum also covers my interests — my research is on tumor immunology — and the numerous distractions in New York City are quite appealing!

Fellowships

Ruth L. Kirschstein Predoctoral Individual National Research Service Award (NIH F31) (2017-2019)

Geoffrey Beene Graduate Student Fellowship (2015-2016)

Publications

Kuhn NF, Lopez AV, Li X, Cai W, Daniyan AF, Brentjens RJ. (2020) CD103⁺ cDC1 and endogenous CD8⁺ T cells are necessary for improved CD40L-overexpressing CAR T cell antitumor function.Nat Commun. 11. 6171.

Kuhn NF, Purdon TJ, van Leeuwen DG, Lopez AV, Curran KJ, Daniyan AF, Brentjens RJ; (2019) CD40 Ligand-Modified Chimeric Antigen Receptor T Cells Enhance Antitumor Function by Eliciting an Endogenous Antitumor Response.Cancer Cell. 35, 473-488. PMCID: PMC6428219.

Malandro N, Budhu S, Kuhn NF, Liu C, Murphy JT, Cortez C, Zhong H, Yang X, Rizzuto G, Altan-Bonnet G, Merghoub T, Wolchok JD. (2016) Clonal Abundance of Tumor-Specific CD4(+) T Cells Potentiates Efficacy and Alters Susceptibility to Exhaustion. Immunity, 44, 179-93.

Berger A, Quast SA, Plötz M, Kuhn NF, Trefzer U, Eberle J. (2014) RAF Inhibition Overcomes Resistance to TRAIL-Induced Apoptosis in Melanoma Cells. J Invest Dermatol., 134, 430-40.

View a full listing of Nicholas F. Kuhn’s journal articles.