Ivan J. Cohen

Email

[email protected]

Dissertation

Tumor glycolysis is a mechanism of immune exclusion in solid tumors (2019)

Mentor

Ronald G. Blasberg

Start Year

2013

End Year

2019

Education

BA/MA, Hunter College

I have always been interested in cancer research, and Memorial Sloan Kettering is one of the top cancer centers in the world. For me, deciding on a graduate school was easy. I knew the research environment at Gerstner Sloan Kettering would provide me with the best opportunity to do truly meaningful cancer research. I’m interested in both translational cancer research and microscopic imaging. Luckily, my current project combines both of these passions to allow me to better understand the role of immune cells in fighting aggressive breast cancer. When I’m not in the lab, I like to play soccer on the public fields in New York City. People from all over the world meet up there and play for hours.

Publications

Zappasodi R, Serganova I, Cohen IJ, Maeda M, Shindo M, Senbabaoglu Y, Watson MJ, Leftin A, Maniyar R, Verma S, Lubin M, Ko M, Mane MM, Zhong H, Liu C, Ghosh A, Abu-Akeel M, Ackerstaff E, Koutcher JA, Ho PC, Delgoffe GM, Blasberg R, Wolchok JD, Merghoub T. (2021) CTLA-4 blockade drives loss of T_reg stability in glycolysis-low tumours. Nature [Online ahead of print]

Mane MM, Cohen IJ, Ackerstaff E, Shalaby K, Ijoma JN, Ko M, Maeda M, Albeg AS, Vemuri K, Satagopan J, Moroz A, Zurita J, Shenker L, Shindo M, Nickles T, Nikolov E, Moroz MA, Koutcher JA, Serganova I, Ponomarev V, Blasberg RG.(2020) Lactate Dehydrogenase A Depletion Alters MyC-CaP Tumor Metabolism, Microenvironment, and CAR T Cell Therapy. Mol Ther Oncolytics 18 382-395,

Serganova I, Cohen IJ, Vemuri K, Shindo M, Maeda M, Mane M, Moroz E, Khanin R, Satagopan J, Koutcher JA, Blasberg R. (2018) LDH-A regulates the tumor microenvironment via HIF-signaling and modulates the immune response. PLoS One 13, e0203965.

Cohen I, Blasberg R. (2017) Impact of the Tumor Microenvironment on Tumor-Infiltrating Lymphocytes: Focus on Breast Cancer. Breast Cancer (Auckl) 11. PMCID: PMC5617083

Serganova I, Moroz E, Cohen I, Moroz M, Mane M, Zurita J, Shenker L, Ponomarev V, Blasberg R. (2016) Enhancement of PSMA-Directed CAR Adoptive Immunotherapy by PD-1/PD-L1 Blockade. Mol Ther Oncolytics. 14 41-54. PMCID: PMC5363727

View a full listing of Ivan J. Cohen’s journal articles.

Ivan J. Cohen, PhD