Senior Scientist, 2015-present
AbbVie
Chicago, Illinois

PhD, University of Notre Dame, 2012

BS, Nanjing University, 2007

Publications

• Designed small-molecule inhibitors of the Anthranilyl-CoA synthetase PqsA block quinolone biosynthesis in Pseudomonas aeruginosa.
  Cheng J.†; Sharma, I. †; Pratihar, I.†;Hudson, L.; Maura, D.; Guney, T.; Rahme, L. G.; Pesci, E. C.; Coleman, J. P.; Tan, D. S.*; ACS Chem. Biol. 2016
  [ Abstract | PubMed ]
• Iron transport-mediated drug delivery: Practical syntheses and in vitro antibacterial studies of tris-catecholate siderophore-aminopenicillin conjugates reveals selectively potent antipseudomonal activity.
  Ji, C.; Miller, P. A.; Miller, M. J.* J. Am. Chem. Soc. 2012, 134, 9898–9901.
  [ Abstract | PubMed ]
• Chemical syntheses and in vitro antibacterial activity of two desferrioxamine B-ciprofloxacin conjugates with potential esterase and phosphatase triggered drug release linkers.
  Ji, C.; Miller, M. J.* Bioorg. Med. Chem. 2012, 20, 3828–3836.
  [ Abstract | PubMed ]
• Syntheses and biological studies of novel spiropiperazinyl oxazolidinone antibacterial agents using a spirocyclic diene derived acylnitroso Diels−Alder reaction.
  Ji, C.; Lin, W.; Moraski, G. C.; Thanassi, J. A.; Pucci, M. J.; Franzblau, S. G.; Möllmann, U.; Miller, M. J.* Bioorg. Med. Chem. 2012, 20, 3422–3428.
  [ Abstract | PubMed ]
• Exploiting bacterial iron acquisition: Siderophore conjugates.
  Ji, C.; Juárez-Hernández R. E.; Miller, M. J.* Future Med. Chem. 2012, 4, 297–313.
  [ Abstract | PubMed ]
• Reactivity of the 16e (p-cymene)Ru half-sandwich complex containing a chelating 1,2-dicarba-closo-dodecaborane-1,2-dithiolate ligand towards diynes .
  Xu, Z. W.; Han, L.; Ji, C.; Zhang, R.; Shen, X. J.; Yan, H.* Dalton Trans. 2011, 40, 6992–6997.
  [ Abstract | PubMed ]
• Cyclopropanation of nitroso Diels–Alder cycloadducts and application to the synthesis of a 2′,3′-methano carbocyclic nucleoside.
  Ji, C.; Miller, M. J.* Tetrahedron Lett. 2010, 51, 3789–3791.
  [ Abstract | PubMed | PMC ]
• A novel dinuclear ruthenium(I)/ruthenium(III) half-sandwich complex containing two chelating 1,2-dicarba-closo-dodecaborane-1,2-dithiolate ligands and its reactivity with alkynes.
  Wu, D. H.; Ji, C.; Li, Y. Z.; Yan, H.* Organometallics 2007, 26, 1560–1562.
  [ Abstract ]
• Obacunone.
  Zhou, X.; Ji, C.; Fu, J.; Li, Y. G.* Acta Crystallogr., Sect. E: Struct. Rep. Online 2006, 62, O5544–O5546.
  [ Abstract ]