View a full listing of Karuna Ganesh: Publications’ journal articles.
Progressive plasticity during colorectal cancer metastasis. Moorman AR, Cambuli F, Benitez EK, Jiang Q, Xie Y, Mahmoud A, Lumish M, Hartner S, Balkaran S, Bermeo J, Asawa S, Firat C, Saxena A, Luthra A, Sgambati V, Luckett K, Wu F, Li Y, Yi Z, Masilionis I, Soares K, Pappou E, Yaeger R, Kingham P, Jarnagin W, Paty P, Weiser MR, Mazutis L, D’Angelica M, Shia J, Garcia-Aguilar J, Nawy T, Hollmann TJ, Chaligné R, Sanchez-Vega F, Sharma R, Pe’er D, Ganesh K. bioRxiv. 2023 Aug 21:2023.08.18.553925. doi: 10.1101/2023.08.18.553925. PMID: 37662289; PMCID: PMC10473595.
Metastasis. Ganesh K, Gerstberger S, Jiang Q, Cell. 2023 Apr 13;186(8):1564-1579. doi:10.1016/j.cell.2023.03.003. PMID: 37059065
Uncoupling metastasis from tumorigenesis. Ganesh K. N Engl J Med. 2023 Feb 16;388(7):657-659. doi: 10.1056/NEJMcibr2213497. PMID: 36791168 Free PMC article.
L1CAM defines the regenerative origin of metastasis-initating cells in colorectal cancer. Ganesh K, Basnet H, Kaygusuz Y, Laughney AM, He L, Sharma R, O’Rourke KP, Reuter VP, Huang YH, Turkekul M, Er EE, Masilionis I, Manova-Todorova K, Weiser MR, Saltz LB, Garcia-Aguilar J, Koche R, Lowe SW, Pe’er D, Shia J, Massagué J. Nat Cancer. 2020 Jan;1(1):28-45. doi: 10.1038/s43018-019-0006-x. Epub 2020 Jan 13. PMID: 32656539
A rectal cancer organoid platform to study individual responses to chemoradiation. Ganesh K, Wu C, O’Rourke KP, Szeglin BC, Zheng Y, Sauvé CG, Adileh M, Wasserman I, Marco MR, Kim AS, Shady M, Sanchez-Vega F, Karthaus WR, Won HH, Choi SH, Pelossof R, Barlas A, Ntiamoah P, Pappou E, Elghouayel A, Strong JS, Chen CT, Harris JW, Weiser MR, Nash GM, Guillem JG, Wei IH, Kolesnick RN, Veeraraghavan H, Ortiz EJ, Petkovska I, Cercek A, Manova-Todorova KO, Saltz LB, Lavery JA, DeMatteo RP, Massagué J, Paty PB, Yaeger R, Chen X, Patil S, Clevers H, Berger MF, Lowe SW, Shia J, Romesser PB, Dow LE, Garcia-Aguilar J, Sawyers CL, Smith JJ. Nat Med. 2019 Oct;25(10):1607-1614. doi: 10.1038/s41591-019-0584-2. Epub 2019 Oct 7.PMID: 31591597
Gerstberger S, Ganesh K. NEN in a dish: A patient-derived organoid biobank illuminates potential novel therapeutic opportunities for neuroendocrine neoplasms. Cancer Cell. 2023 Dec 11;41(12):2014-2016. doi: 10.1016/j.ccell.2023.11.006. PMID: 38086333.
Kudelka MR, Abou-Alfa GK, O’Reilly EM, Foote MB, Sirohi B, Elias R, Shamseddine A, Paroder V, Moussa AM, Cohen P, Ganesh K. Metastatic well differentiated serotonin-producing pancreatic neuroendocrine tumor with carcinoid heart disease. J Gastrointest Oncol. 2023 Aug 31;14(4):1878-1886. doi: 10.21037/jgo-22-909. Epub 2023 Aug 23. PMID: 37720425; PMCID: PMC10502540.
Mahmoud A, Ganesh K. Mouse models of metastasis and dormancy. Cold Spring Harb Perspect Med. 2023 Sep 11:a041386. doi: 10.1101/cshperspect.a041386. Epub ahead of print. PMID: 37696656.
Kim M, Panagiotakopoulou M, Chen C, Ruiz SB, Ganesh K, Tammela T, Heller DA. Micro-engineering and nano-engineering approaches to investigate tumour ecosystems. Nat Rev Cancer. 2023 Sep;23(9):581-599. doi: 10.1038/s41568-023-00593-3. Epub 2023 Jun 23. PMID: 37353679; PMCID: PMC10528361.
Gerstberger S, Jiang Q, Ganesh K. Metastasis. Cell. 2023 Apr 13;186(8):1564-1579. doi: 10.1016/j.cell.2023.03.003. PMID: 37059065; PMCID: PMC10511214.
Hu J, Sánchez-Rivera FJ, Wang Z, Johnson GN, Ho YJ, Ganesh K, Umeda S, Gan S, Mujal AM, Delconte RB, Hampton JP, Zhao H, Kottapalli S, de Stanchina E, Iacobuzio-Donahue CA, Pe’er D, Lowe SW, Sun JC, Massagué J. STING inhibits the reactivation of dormant metastasis in lung adenocarcinoma. Nature. 2023 Apr;616(7958):806-813. doi: 10.1038/s41586-023-05880-5. Epub 2023 Mar 29. PMID: 36991128; PMCID: PMC10569211.
Ganesh K. Uncoupling metastasis from tumorigenesis. N Engl J Med. 2023 Feb 16;388(7):657-659. doi: 10.1056/NEJMcibr2213497. PMID: 36791168; PMCID: PMC10375401.
Diamond B, Ziccheddu B, Maclachlan K, Taylor J, Boyle E, Ossa JA, Jahn J, Affer M, Totiger TM, Coffey D, Chandhok N, Watts J, Cimmino L, Lu SX, Bolli N, Bolton K, Landau H, Park JH, Ganesh K, McPherson A, Sekeres MA, Lesokhin A, Chung DJ, Zhang Y, Ho C, Roshal M, Tyner J, Nimer S, Papaemmanuil E, Usmani S, Morgan G, Landgren O, Maura F. Tracking the evolution of therapy-related myeloid neoplasms using chemotherapy signatures. Blood. 2023 May 11;141(19):2359-2371. doi: 10.1182/blood.2022018244. PMID: 36626250; PMCID: PMC10273163.
Chatila WK, Walch H, Hechtman JF, Moyer SM, Sgambati V, Faleck DM, Srivastava A, Tang L, Benhamida J, Ismailgeci D, Campos C, Wu F, Chang Q, Vakiani E, de Stanchina E, Weiser MR, Widmar M, Yantiss RK, Shah MA, Bass AJ, Stadler ZK, Katz LH, Mellinghoff IK, Sethi NS, Schultz N, Ganesh K, Kelsen D, Yaeger R. Integrated clinical and genomic analysis identifies driver events and molecular evolution of colitis-associated cancers. Nat Commun. 2023 Jan 7;14(1):110. doi: 10.1038/s41467-022-35592-9. PMID: 36611031; PMCID: PMC9825391.
Chatila WK, Kim JK, Walch H, Marco MR, Chen CT, Wu F, Omer DM, Khalil DN, Ganesh K, Qu X, Luthra A, Choi SH, Ho YJ, Kundra R, Groves KI, Chow OS, Cercek A, Weiser MR, Widmar M, Wei IH, Pappou EP, Nash GM, Paty PB, Shi Q, Vakiani E, Duygu Selcuklu S, Donoghue MTA, Solit DB, Berger MF, Shia J, Pelossof R, Romesser PB, Yaeger R, Smith JJ, Schultz N, Sanchez-Vega F, Garcia-Aguilar J. Genomic and transcriptomic determinants of response to neoadjuvant therapy in rectal cancer. Nat Med. 2022 Aug;28(8):1646-1655. doi: 10.1038/s41591-022-01930-z. Epub 2022 Aug 15. PMID: 35970919; PMCID: PMC9801308.
Niec RE, Chu T, Schernthanner M, Gur-Cohen S, Hidalgo L, Pasolli HA, Luckett KA, Wang Z, Bhalla SR, Cambuli F, Kataru RP, Ganesh K, Mehrara BJ, Pe’er D, Fuchs E. Lymphatics act as a signaling hub to regulate intestinal stem cell activity. Cell Stem Cell. 2022 Jul 7;29(7):1067-1082.e18. doi: 10.1016/j.stem.2022.05.007. Epub 2022 Jun 20. PubMed PMID: 35728595; PubMed Central PMCID: PMC9271639.
Sihag S, Nussenzweig SC, Walch HS, Hsu M, Tan KS, De La Torre S, Janjigian YY, Maron SB, Ku GY, Tang LH, Shah PM, Wu A, Jones DR, Solit DB, Schultz N, Ganesh K, Berger MF, Molena D. The Role of the TP53 Pathway in Predicting Response to Neoadjuvant Therapy in Esophageal Adenocarcinoma. Clin Cancer Res. 2022 Jun 13;28(12):2669-2678. doi: 10.1158/1078-0432.CCR-21-4016. PubMed PMID: 35377946; PubMed Central PMCID: PMC9197876.
Schapiro D, Yapp C, Sokolov A, Reynolds SM, Chen YA, Sudar D, Xie Y, Muhlich J, Arias-Camison R, Arena S, Taylor AJ, Nikolov M, Tyler M, Lin JR, Burlingame EA, Chang YH, Farhi SL, Thorsson V, Venkatamohan N, Drewes JL, Pe’er D, Gutman DA, Herrmann MD, Gehlenborg N, Bankhead P, Roland JT, Herndon JM, Snyder MP, Angelo M, Nolan G, Swedlow JR, Schultz N, Merrick DT, Mazzili SA, Cerami E, Rodig SJ, Santagata S, Sorger PK. MITI minimum information guidelines for highly multiplexed tissue images. Nat Methods. 2022 Mar;19(3):262-267. doi: 10.1038/s41592-022-01415-4. PubMed PMID: 35277708; PubMed Central PMCID: PMC9009186.
Nguyen B, Fong C, Luthra A, Smith SA, DiNatale RG, Nandakumar S, Walch H, Chatila WK, Madupuri R, Kundra R, Bielski CM, Mastrogiacomo B, Donoghue MTA, Boire A, Chandarlapaty S, Ganesh K, Harding JJ, Iacobuzio-Donahue CA, Razavi P, Reznik E, Rudin CM, Zamarin D, Abida W, Abou-Alfa GK, Aghajanian C, Cercek A, Chi P, Feldman D, Ho AL, Iyer G, Janjigian YY, Morris M, Motzer RJ, O’Reilly EM, Postow MA, Raj NP, Riely GJ, Robson ME, Rosenberg JE, Safonov A, Shoushtari AN, Tap W, Teo MY, Varghese AM, Voss M, Yaeger R, Zauderer MG, Abu-Rustum N, Garcia-Aguilar J, Bochner B, Hakimi A, Jarnagin WR, Jones DR, Molena D, Morris L, Rios-Doria E, Russo P, Singer S, Strong VE, Chakravarty D, Ellenson LH, Gopalan A, Reis-Filho JS, Weigelt B, Ladanyi M, Gonen M, Shah SP, Massague J, Gao J, Zehir A, Berger MF, Solit DB, Bakhoum SF, Sanchez-Vega F, Schultz N. Genomic characterization of metastatic patterns from prospective clinical sequencing of 25,000 patients. Cell. 2022 Feb 3;185(3):563-575.e11. doi: 10.1016/j.cell.2022.01.003. PubMed PMID: 35120664; PubMed Central PMCID: PMC9147702.
Ganesh K. Optimizing immunotherapy for colorectal cancer. Nat Rev Gastroenterol Hepatol. 2022 Feb;19(2):93-94. doi: 10.1038/s41575-021-00569-4. Review. PubMed PMID: 34907331; PubMed Central PMCID: PMC9487162.
Jiang Q, Ganesh K. Breaking up MTDH-SND1 to break down metastasis. Nat Cancer. 2022 Jan;3(1):6-8. doi: 10.1038/s43018-021-00320-7. PubMed PMID: 35121995; NIHMSID:NIHMS1816516.
Weiser MR, Chou JF, Keshinro A, Chapman WC Jr, Bauer PS, Mutch MG, Parikh PJ, Cercek A, Saltz LB, Gollub MJ, Romesser PB, Crane CH, Shia J, Markowitz AJ, Garcia-Aguilar J, Gönen M. Development and Assessment of a Clinical Calculator for Estimating the Likelihood of Recurrence and Survival Among Patients With Locally Advanced Rectal Cancer Treated With Chemotherapy, Radiotherapy, and Surgery. JAMA Netw Open. 2021 Nov 1;4(11):e2133457. doi: 10.1001/jamanetworkopen.2021.33457. PubMed PMID: 34748003; PubMed Central PMCID: PMC8576585.
Cercek A, Chatila WK, Yaeger R, Walch H, Fernandes GDS, Krishnan A, Palmaira L, Maio A, Kemel Y, Srinivasan P, Bandlamudi C, Salo-Mullen E, Tejada PR, Belanfanti K, Galle J, Joseph V, Segal N, Varghese A, Reidy-Lagunes D, Shia J, Vakiani E, Mondaca S, Mendelsohn R, Lumish MA, Steinruecke F, Kemeny N, Connell L, Ganesh K, Markowitz A, Nash G, Guillem J, Smith JJ, Paty PB, Zhang L, Mandelker D, Birsoy O, Robson M, Offit K, Taylor B, Berger M, Solit D, Weiser M, Saltz LB, Aguilar JG, Schultz N, Diaz LA, Stadler ZK. A Comprehensive Comparison of Early-Onset and Average-Onset Colorectal Cancers. J Natl Cancer Inst. 2021 Aug 18;. doi: 10.1093/jnci/djab124. [Epub ahead of print] PubMed PMID: 34405229; PubMed Central PMCID: PMC8634406.
Keshinro A, Vanderbilt C, Kim JK, Firat C, Chen CT, Yaeger R, Ganesh K, Segal NH, Gonen M, Shia J, Stadler Z, Weiser MR. Tumor-Infiltrating Lymphocytes, Tumor Mutational Burden, and Genetic Alterations in Microsatellite Unstable, Microsatellite Stable, or Mutant POLE/POLD1 Colon Cancer. JCO Precis Oncol. 2021;5. doi: 10.1200/PO.20.00456. eCollection 2021. PubMed PMID: 34250404; PubMed Central PMCID: PMC8232557.
Cruz-Hernández E, Mahmood U, Golia Pernicka JS, Paroder V, Petkovska I, Gollub MJ, Shia J, Ganesh K, Bates DDB. Initial evaluation of dual-energy computed tomography as an imaging biomarker for hepatic metastases from neuroendocrine tumor of the gastrointestinal tract. Quant Imaging Med Surg. 2021 May;11(5):2085-2092. doi: 10.21037/qims-20-917. PubMed PMID: 33936989; PubMed Central PMCID: PMC8047339.
Segal NH, Cercek A, Ku G, Wu AJ, Rimner A, Khalil DN, Reidy-Lagunes D, Cuaron J, Yang TJ, Weiser MR, Romesser PB, Stadler ZK, Varghese AM, Ganesh K, Yaeger R, Connell LC, Faleck D, Abou-Alfa GK, Mcauliffe KC, Vaiskauskas P, Solter ML, Ogle M, Adamow MJ, Holland A, Vedantam P, Wong P, Merghoub T, Vakiani E, Hollmann TJ, Juluru K, Chou JF, Capanu M, Erinjeri J, Solomon S, Yamada Y, Kemeny N, Crane CH, Saltz LB. Phase II Single-arm Study of Durvalumab and Tremelimumab with Concurrent Radiotherapy in Patients with Mismatch Repair-proficient Metastatic Colorectal Cancer. Clin Cancer Res. 2021 Apr 15;27(8):2200-2208. doi: 10.1158/1078-0432.CCR-20-2474. Epub 2021 Jan 27. PubMed PMID: 33504552; PubMed Central PMCID: PMC8499477.