Featured Publications

Choi J, Park JE, Tsagkogeorga G, Koo BK, Han N, and Lee JH. Inflammatory signals induce AT2 cell-derived Damage-Associated Transient Progenitors that mediate alveolar regeneration.

Cell Stem Cell. 2020 Sep 3;27(3):366-82.e7.

Featured in the News & Views in Nat Cell Biol. 22:1025-26. Selected as Best of Cell Stem Cell 2020.

Choi J, Jang YJ, Dabrowska C, Iich E, Evans K.V, Hall H, Janes S.M, Simons B.D, Koo BK, Kim J, Lee JH. Release of Notch signalling coordinated by inflammation confers cross-compartment differentiation plasticity during alveolar regeneration. Nature Cell Biology. 2021 Sep;23(9):953-966.

Featured in the News & Views in Nat Cell Biol. 23(9):928-929.

Youk J, Kim T, Evans K.V, Jeong YI, Hur Y, Hong SP, Kim JH, Yi K, Kim SY, Na KJ, Bleazard T, Kim HM, Fellows M, Mahbubani K.T, Saeb-Parsy K, Kim SY, Kim YT, Koh GY, Choi BS, Ju YS, Lee JH. Three-dimensional human alveolar stem cell culture models reveal infection response to SARS-CoV-2. Cell Stem Cell. 2020 Dec 3;27(6):905-19.e10.

Featured in in the News Feature in Nature. 593(7860):492-494.

Ombrato L, Nolan E, Kurelac I, Mavousian A, Bridgeman V, Heinze I, Chakravarty P, Horswell S, Gonzales-Gualda E, Matacchione G, Weston A, Kirkpatrick J, Husain E, Speirs V, Collinson L, Ori A, Lee JH#, Malanchi I#. Metastatic-niche labelling reveals parenchymal cells with stem features. Nature. 2019 Aug;572(7771):603-08.

Featured in the Research Highlights of Nat. Rev. Cancer. 19:605

Selected Peer-Reviewed Publications

(#co-corresponding author; *co-first author)

Lee W, Lee S, Yoon JK, Lee D, Kim Y, Han YB, Kim R, Moon, S, Park YJ, Park K, Cha B, Choi J, Kim J, Ha NY, Kim K, Cho S, Cho NH, Desai T.J., Chung JH, Lee JH#, Kim JI#. A single cell atlas of in vitro multi-systems uncovers in vivo lineage trajectory and cell state in the human lung. Experimental & Molecular Medicine. 2023 Aug;55:1831-1842. https://doi.org/10.1038/s12276-023-01076-z

Jeon HY, Choi J, Kraaier L, Kim YH, Eisenbarth D, Yi K, Jik JW, Shim HS, Lee JH#, and Lim DS#. Airway secretory cell fate conversion via YAP-mTORC1-dependent essential amino acid metabolism. EMBO Journal. 2022 Mar 14;e109365. DOI: https://doi.org/10.15252/embj.2021109365

Choi J, Jang YJ, Dabrowska C, Iich E, Evans K.V, Hall H, Janes S.M, Simons B.D, Koo BK, Kim J#, Lee JH#. Release of Notch signalling coordinated by inflammation confers cross-compartment differentiation plasticity during alveolar regeneration. Nature Cell Biology. 2021 Sep;23(9):953-966. DOI: https://doi.org/10.1038/s41556-021-00742-6

Liu Y, Dabrowska C, Mavousian A, Strauss B, Meng F, Mazzaglia C, Ouaras K, Macintosh C, Terentijev E, Lee JH#, Huang YYS#. Bio-assembling Macro-Scale, Lumenized Airway Tubes of Defined Shape via Multi-Organoid Patterning and Fusion. Advanced Science. 2021 Feb 8;8(9):2003332. DOI: https://doi.org/10.1002/advs.202003332

Youk J, Kim T, Evans K.V, Jeong YI, Hur Y, Hong SP, Kim JH, Yi K, Kim SY, Na KJ, Bleazard T, Kim HM, Fellows M, Mahbubani K.T, Saeb-Parsy K, Kim SY, Kim YT#, Koh GY#, Choi BS#, Ju YS#, Lee JH#. Three-dimensional human alveolar stem cell culture models reveal infection response to SARS-CoV-2. Cell Stem Cell. 2020 Dec 3;27(6):905-19.e10. DOI: https://doi.org/10.1016/j.stem.2020.10.004

Choi J, Park JE, Tsagkogeorga G, Koo BK, Han N, and Lee JH. Inflammatory signals induce AT2 cell-derived Damage-Associated Transient Progenitors that mediate alveolar regeneration.

Cell Stem Cell. 2020 Sep 3;27(3):366-82.e7. DOI: https://doi.org/10.1016/j.stem.2020.06.020

Ombrato L, Nolan E, Kurelac I, Mavousian A, Bridgeman V, Heinze I, Chakravarty P, Horswell S, Gonzales-Gualda E, Matacchione G, Weston A, Kirkpatrick J, Husain E, Speirs V, Collinson L, Ori A, Lee JH#, Malanchi I#. Metastatic-niche labelling reveals parenchymal cells with stem features. Nature. 2019 Aug;572(7771):603-08. DOI: https://doi.org/10.1038/s41586-019-1487-6

Lee JH#, Tammela T, Hofree M, Choi J, Marjanovic N.D, Han S, Canner D.A, Wu K, Paschini M, Bhang D.H, Jacks T, Regev A, Kim C.F#. Anatomically and functionally distinct lung mesenchymal populations marked by Lgr5 and Lgr6. Cell. 2017 Sep 7;170(6):1149-1163. DOI: https://doi.org/10.1016/j.cell.2017.07.028

Lee JH, Bhang D.H, Beede A, Huang T.L, Stripp B.R, Bloch K.D, Wagers A.J, Tseng Y.H, Ryeom S., Kim C.F. Lung stem cell differentiation in mice directed by endothelial cells via a BMP4-NFATc1-Thrombospondin-1 axis. Cell. 2014 Jan 30;156(3):440-55. DOI: https://doi.org/10.1016/j.cell.2013.12.039

Lee KP*, Lee JH*, Kim TS, Park HD, Byun JS, Kim MC, Jeong WI, Calvisi D.F, Kim JM and Lim DS. The Hippo–Salvador pathway restrains hepatic oval cell proliferation, liver size, and liver tumorigenesis. PNAS. 2010 May 4;107(18):8248-53. DOI: https://doi.org/10.1073/pnas.0912203107

Lee JH, Kim TS, Yang TH, Koo BK, Oh SP, Lee KP, Oh HJ, Lee SH, Kong YY, Kim JM, and Lim DS. A crucial role of WW45 in epithelial tissues in the mouse. EMBO J. 2008 Apr 23;27(8):1231-42. DOI: https://doi.org/10.1038/emboj.2008.63

Selected Review Articles and Book Chapter

Chudziak J, Lee JH. Maintaining the barrier: New tactics to protect our breathing. J Cell Biol. 2023 Dec 4;222(12):e202311006. https://doi.org/10.1083/jcb.202311006 Epub 2023 Nov 8.

Varankar S, Cardoso E.C., Lee JH. Ex situ-armus: Experimental models for combating respiratory dysfunction. Current Opinion in Genetics & Development. 2022 Aug;75:101946. https://doi.org/10.1016/j.gde.2022.101946

Dabrowska C, Li J, Mulay A, Carraro G, Gupta M, Kim, CF#, Lee JH#, Stripp BR#. Adult mouse intralobar airway stem cells. European Respiratory Society Monograph Book Chapter “Lung Stem Cells in Development, Health and Disease”. https://doi.org/10.1183/2312508X.10009120

Evans K.V. and Lee JH. Alveolar Wars: The rise of in vitro models to understand human lung alveolar maintenance, regeneration, and disease. Stem Cells Translational Medicine. 2020 Aug;9(8):867-881. https://doi.org/10.1002/sctm.19-0433

Lee JH and Rawlins EL. Developmental mechanisms and adult stem cells for therapeutic lung regeneration. Developmental Biology. 2018 Jan 15;433(2):166-176. https://doi.org/10.1016/j.ydbio.2017. 09.016

Choi J, Iich E, Lee JH. Organogenesis of adult lung in a dish: Differentiation, disease and therapy. Developmental Biology. 2016 Dec 15;420(2):278-286. https://doi.org/10.1016/j.ydbio.2016.10.002

Lee JH, Kim CF. Developmental biology. Mesenchymal progenitor panoply. Science. 2014 Nov 14;346(6211):810-1. https://doi.org/10.1126/science.aaa0609