Chemical Biology Program

The Heeseon An Lab

Heeseon An, PhD

Assistant Professor

The research in An lab centers around protein degradation processes in health and disease. We investigate protein degradation processes using chemical biology tools and unbiased proteomic approaches to discover previously unknown degradational pathways and molecular mechanisms. Specific research areas include 1) developing innovative chemical, biological, and proteomic tools to help advance protein degradation research, 2) identifying protein degradation pathways altered explicitly in disease and employing this information to develop small molecule probes with therapeutic potential, and 3) elucidating the fundamental role of ribosomal proteins and ribosome homeostasis using protein-degradation and chemical proteomics tools. Multidisciplinary and quantitative approaches are central to our research in addressing the questions mentioned above.

Publications Highlights

Pham BQ, Yi SA, Ordureau A, An H^* (2024) mTORC1 regulates the pyrimidine salvage pathway by controlling UCK2 turnover via the CTLH-WDR26 E3 ligase. Cell Reports , accepted

Yi SA, Sepic S, Schulman BA, Ordureau A, An H^* (2024) mTORC1-CTLH E3 ligase regulates the degradation of HMG-CoA synthase 1 through the Pro/N-degron pathway. Molecular Cell , 84, 1-19.

Jordan VN, Ordureau A, An H^* (2023) Identifying E3 ligase substrates with quantitative degradation proteomics. Chembiochem . 24(16):e202300108.

An H^#, Ordureau A^#, Koerner M, Paulo JA, Harper JW (2020) Systematic quantitative analysis of ribosome inventory during nutrient stress. Nature , 583, 303-309. # equal contribution

An H, Ordureau A, Paulo JA, Shoemaker CJ, Denic V, Harper JW (2019) TEX264 Is an Endoplasmic Reticulum-Resident ATG8-Interacting Protein Critical for ER Remodeling during Nutrient Stress. Molecular Cell , 74, 891-908.

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People

Heeseon An, PhD

Assistant Professor

Heeseon An’s lab studies protein degradation in health and disease using chemical, biological, and proteomics tools.
BS and MS, Chemistry, Seoul National University
PhD, Chemistry, Northwestern University
Postdoc, Cell Biology, Harvard Medical School

[email protected]: Email Address
646-888-3417 (ZRC-2003): Office Phone
Download CV: PDF File

Members

Ersilia Barin
WCM Pharm graduate student

Victoria Jordan
TPCB graduate student (NSF Graduate Research Fellow)

Brittany Pham
WCM Pharm graduate student

Karl Lin
TPCB graduate student (NSF Graduate Research Fellow)

Deepika Nambiar
TPCB graduate student (NSF Graduate Research Fellow)

Pascale Presendor
Administrative Assistant

Michelle (Ruiyang) Guo
TPCB graduate student (joint with Huse lab)

Lab Alumni

Mel-Quann Hodge

Administrative Assistant

Lab Affiliations

Achievements

Josie Robertson Investigator (2020-2025)

Open Positions

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Career Opportunities

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Get in Touch

[email protected]

Lab Head Email
646-888-3417 (ZRC-2003)

Office Phone

Disclosures

Doctors and faculty members often work with pharmaceutical, device, biotechnology, and life sciences companies, and other organizations outside of MSK, to find safe and effective cancer treatments, to improve patient care, and to educate the health care community.

MSK requires doctors and faculty members to report (“disclose”) the relationships and financial interests they have with external entities. As a commitment to transparency with our community, we make that information available to the public.

Heeseon An discloses the following relationships and financial interests:

No disclosures meeting criteria for time period

The information published here is a complement to other publicly reported data and is for a specific annual disclosure period. There may be differences between information on this and other public sites as a result of different reporting periods and/or the various ways relationships and financial interests are categorized by organizations that publish such data.

This page and data include information for a specific MSK annual disclosure period (January 1, 2023 through disclosure submission in spring 2024). This data reflects interests that may or may not still exist. This data is updated annually.

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