Cancer Biology & Genetics Program
The Christine Mayr Lab
Research
![Christine Mayr](https://www.sloankettering.edu/sites/default/files/styles/width_200_1x1/public/node/4967/main_image/mayr-1200x800.jpg?h=10d202d3)
Professor
My laboratory studies the regulatory and structural roles of mRNAs in the cytoplasm. Specifically, we investigate how 3′UTRs regulate protein functions in a manner that is independent of protein abundance.
We found that inclusion or exclusion of the 3′UTR of an mRNA that encodes a transcription factor did not change how much of the transcription factor protein was expressed but determined the location of protein synthesis of the transcription factor as well as its induced gene expression program. Moreover, we observed that expression of a chromatin regulator from an mRNA with or without its 3′UTR resulted in similar expression of the protein in the nucleus but changed the enzymatic activity of the chromatin regulator in the nucleus.
If you are interested in this topic, please contact me as we have open positions for postdocs and graduate students from diverse backgrounds.
Research Projects
Featured News
![Ellen Horste](https://www.sloankettering.edu/sites/default/files/styles/width_200/public/node/304111/main_image/msk-discoveries-beyond-the-bench-240528-017-rt_1200x800.jpg)
![Christine Mayr](https://www.sloankettering.edu/sites/default/files/styles/width_200/public/node/291456/main_image/mayr-christina-220613-002_rt_1200x800-1.jpg)
![3D organelle](https://www.sloankettering.edu/sites/default/files/styles/width_200/public/node/166831/3x2/mcherry-zfp36l1-gfp-sec61b-63x-zoom10-z-stack5_cropped_2018-01-17t13-34-48.849_3x2_0.jpg)
Publications Highlights
Horste, E.L., Fansler, M.M., Cai, T., Chen, X., Mitschka, S., Zhen, G., Lee, F.C.Y., Ule, J., and Mayr, C. (2023). Subcytoplasmic location of translation controls protein output. Mol Cell 83, 4509-4523.e4511.
Chen, X., Fansler, M.M., Janjoš, U., Ule, J., and Mayr, C. (2024). The FXR1 network acts as signaling scaffold for actomyosin remodeling. Cell, in press. Also on bioRxiv, 2023.2011.2005.565677.
People
![Christine Mayr](https://www.sloankettering.edu/sites/default/files/styles/width_200_1x1/public/node/4967/main_image/mayr-1200x800.jpg?h=10d202d3)
Christine Mayr, MD, PhD
Professor
- Molecular and cell biologist Christine Mayr studies how 3′UTRs regulate protein functions and how mRNAs contribute to cytoplasmic organization.
- MD, Free University Berlin
- PhD, Humboldt University Berlin
- [email protected]
- Email Address
- Nadine Hernández
- Office Phone
- Download CV
- PDF File
Members
![Mervin Fansler](https://www.sloankettering.edu/sites/default/files/styles/width_200_1x1/public/node/146989/3x2/fansler-mervin_180427_04_1200x800.jpg?h=10d202d3)
![](https://www.sloankettering.edu/sites/default/files/styles/width_200_1x1/public/node/290626/main_image/ting3.jpeg)
![](https://www.sloankettering.edu/sites/default/files/styles/width_200_1x1/public/node/290501/main_image/shraddha_headshot.jpg)
![](https://www.sloankettering.edu/sites/default/files/styles/width_200_1x1/public/node/290531/main_image/hernandez_3x2.jpg)
![](https://www.sloankettering.edu/sites/default/files/styles/width_200_1x1/public/node/257646/main_image/yang-luo.jpeg)
![](https://www.sloankettering.edu/sites/default/files/styles/width_200_1x1/public/node/290506/main_image/lila_headshot.jpg)
![](https://www.sloankettering.edu/sites/default/files/styles/width_200_1x1/public/node/290511/main_image/yaofeng_headshot.jpg)
![Xiuzhen Chen](https://www.sloankettering.edu/sites/default/files/styles/width_200_1x1/public/node/179587/3x2/xiuzhen_3x2.jpg?h=10d202d3)
Research Associate
![Mervin Fansler](https://www.sloankettering.edu/sites/default/files/styles/width_200_1x1/public/node/146989/3x2/fansler-mervin_180427_04_1200x800.jpg?h=10d202d3)
Research Scholar
![](https://www.sloankettering.edu/sites/default/files/styles/width_200_1x1/public/node/290626/main_image/ting3.jpeg)
Research Scholar
![](https://www.sloankettering.edu/sites/default/files/styles/width_200_1x1/public/node/290501/main_image/shraddha_headshot.jpg)
Research Technician
![](https://www.sloankettering.edu/sites/default/files/styles/width_200_1x1/public/node/290531/main_image/hernandez_3x2.jpg)
Senior Administrative Assistant
![](https://www.sloankettering.edu/sites/default/files/styles/width_200_1x1/public/node/257646/main_image/yang-luo.jpeg)
Postdoctoral Fellow
![](https://www.sloankettering.edu/sites/default/files/styles/width_200_1x1/public/node/290506/main_image/lila_headshot.jpg)
Graduate Student
![](https://www.sloankettering.edu/sites/default/files/styles/width_200_1x1/public/node/290511/main_image/yaofeng_headshot.jpg)
Graduate Student
![Shih-Han (Peggy) Lee](https://www.sloankettering.edu/sites/default/files/styles/width_200_1x1/public/node/19496/3x2/lee-shih-han_180427_09_1200x800.jpg?h=10d202d3)
![Ellen Horste](https://www.sloankettering.edu/sites/default/files/styles/width_200_1x1/public/node/142912/3x2/horste-ellen_180727_16_1200x800.jpg?h=10d202d3)
- BS, University of Michigan Ann Arbor
![Buki Kwon](https://www.sloankettering.edu/sites/default/files/styles/width_200_1x1/public/node/136816/3x2/kwon-buki_1180727_08_1200x800.jpg?h=10d202d3)
![Federica Lari](https://www.sloankettering.edu/sites/default/files/styles/width_200_1x1/public/node/136804/3x2/lari-federica_180427_09_1200x800.jpg?h=10d202d3)
![Sibylle Mitschka](https://www.sloankettering.edu/sites/default/files/styles/width_200_1x1/public/node/123661/3x2/mitschka-sibylle_180427_07_1200x800.jpg?h=10d202d3)
![Neil Robertson](https://www.sloankettering.edu/sites/default/files/styles/width_200_1x1/public/node/179584/3x2/neil_3x2.jpg?h=10d202d3)
![Jihye (Sophia) Lee](https://www.sloankettering.edu/sites/default/files/styles/width_200_1x1/public/node/102768/3x2/lee-jihye-3x2.jpg)
![Gang Zhen](https://www.sloankettering.edu/sites/default/files/styles/width_200_1x1/public/node/179581/3x2/gangzhen-1200x800.jpg?h=10d202d3)
![Pia Worrell](https://www.sloankettering.edu/sites/default/files/styles/width_200_1x1/public/node/156799/3x2/worrell_180614_03_1200x800.jpg?h=10d202d3)
![Sarah Tisdale](https://www.sloankettering.edu/sites/default/files/styles/width_200_1x1/public/node/136798/3x2/tisdale-sarah_180427_09_1200x400.jpg)
Lab Alumni
![Shih-Han (Peggy) Lee](https://www.sloankettering.edu/sites/default/files/styles/width_200_1x1/public/node/19496/3x2/lee-shih-han_180427_09_1200x800.jpg?h=10d202d3)
Postdoctoral Fellow
Graduate Student
![Irtisha Singh](https://www.sloankettering.edu/sites/default/files/styles/width_200_1x1/public/node/19498/image/irtisha-copy.jpg)
Graduate Student, Tri-I CBM Program
![Eric Kallin](https://www.sloankettering.edu/sites/default/files/styles/width_200_1x1/public/node/19497/image/eric-kallin.jpg)
Postdoctoral Fellow
![Binyamin Berkovits](https://www.sloankettering.edu/sites/default/files/styles/width_200_1x1/public/node/19495/image/bin-new.jpg)
Postdoctoral Fellow
![Ellen Horste](https://www.sloankettering.edu/sites/default/files/styles/width_200_1x1/public/node/142912/3x2/horste-ellen_180727_16_1200x800.jpg?h=10d202d3)
Scientist/Payload Engineer, Apertura Gene Therapy, New York, NY
![Marie Clemot](https://www.sloankettering.edu/sites/default/files/styles/width_200_1x1/public/node/5910/image/clemot-marie.jpg)
Master Student
![Buki Kwon](https://www.sloankettering.edu/sites/default/files/styles/width_200_1x1/public/node/136816/3x2/kwon-buki_1180727_08_1200x800.jpg?h=10d202d3)
Postdoctoral Fellow
![Omar Hamdani, MPH](https://www.sloankettering.edu/sites/default/files/styles/width_200_1x1/public/node/5289/image/hamdani-omar.jpg)
Research Technician
![Federica Lari](https://www.sloankettering.edu/sites/default/files/styles/width_200_1x1/public/node/136804/3x2/lari-federica_180427_09_1200x800.jpg?h=10d202d3)
Postdoctoral Fellow
![Jessica Johnson](https://www.sloankettering.edu/sites/default/files/styles/width_200_1x1/public/node/12046/image/111107-mayr-lab-024.jpg)
Research Technician
![Weirui Ma](https://www.sloankettering.edu/sites/default/files/styles/width_200_1x1/public/node/123659/3x2/ma-weirui_180427_04_1200x800.jpg?h=10d202d3)
Postdoctoral Fellow
![Vidur Garg](https://www.sloankettering.edu/sites/default/files/styles/width_200_1x1/public/node/19494/image/vidur-garg.jpg)
Research Technician
![Sibylle Mitschka](https://www.sloankettering.edu/sites/default/files/styles/width_200_1x1/public/node/123661/3x2/mitschka-sibylle_180427_07_1200x800.jpg?h=10d202d3)
Senior Research Scientist
![Neil Patel, Medical School](https://www.sloankettering.edu/sites/default/files/styles/width_200_1x1/public/node/24874/image/neilpatel.jpg)
Research technician
![Neil Robertson](https://www.sloankettering.edu/sites/default/files/styles/width_200_1x1/public/node/179584/3x2/neil_3x2.jpg?h=10d202d3)
Postdoctoral Fellow
![Jihye (Sophia) Lee](https://www.sloankettering.edu/sites/default/files/styles/width_200_1x1/public/node/102768/3x2/lee-jihye-3x2.jpg)
Research Technician
![Gang Zhen](https://www.sloankettering.edu/sites/default/files/styles/width_200_1x1/public/node/179581/3x2/gangzhen-1200x800.jpg?h=10d202d3)
Postdoctoral Fellow
![Pia Worrell](https://www.sloankettering.edu/sites/default/files/styles/width_200_1x1/public/node/156799/3x2/worrell_180614_03_1200x800.jpg?h=10d202d3)
Administrative Assistant
![Casey Robinson](https://www.sloankettering.edu/sites/default/files/styles/width_200_1x1/public/node/257656/main_image/casey_1200x800.jpg?h=10d202d3)
Administrative Assistant
![Sarah Tisdale](https://www.sloankettering.edu/sites/default/files/styles/width_200_1x1/public/node/136798/3x2/tisdale-sarah_180427_09_1200x400.jpg)
Postdoctoral Fellow
Lab Affiliations
Achievements
- Luise and Allston Boyer Young Investigator Award for Basic Research (2019)
- NIH Director’s Pioneer Award (2016)
- Pershing Square Sohn Prize for Young Investigators in Cancer Research (2015)
- Damon Runyon-Rachleff Innovation Award, Damon Runyon Cancer Research Foundation (2012)
- Selected as ‘Cell Scientist to watch’ by Journal of Cell Science (2015)
Read more
- Science Signaling Breakthrough of the year (2013)
Open Positions
To learn more about available postdoctoral opportunities, please visit our Career Center
To learn more about compensation and benefits for postdoctoral researchers at MSK, please visit Resources for Postdocs
Career Opportunities
Get in Touch
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Lab Head Email
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Office Phone
Disclosures
Doctors and faculty members often work with pharmaceutical, device, biotechnology, and life sciences companies, and other organizations outside of MSK, to find safe and effective cancer treatments, to improve patient care, and to educate the health care community.
MSK requires doctors and faculty members to report (“disclose”) the relationships and financial interests they have with external entities. As a commitment to transparency with our community, we make that information available to the public.
Christine Mayr discloses the following relationships and financial interests:
No disclosures meeting criteria for time period
The information published here is for a specific annual disclosure period. There may be differences between information on this and other public sites as a result of different reporting periods and/or the various ways relationships and financial interests are categorized by organizations that publish such data.
This page and data include information for a specific MSK annual disclosure period (January 1, 2022 through disclosure submission in spring 2023). This data reflects interests that may or may not still exist. This data is updated annually.
Learn more about MSK’s COI policies here. For questions regarding MSK’s COI-related policies and procedures, email MSK’s Compliance Office at [email protected].