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Sci Immunol. 2021 6(60):eabi4710. Pritykin Y, van der Veeken J, Pine AR, Zhong Y, Sahin M, Mazutis L, Pe’er D, Rudensky AY, Leslie CS. (2021) A unified atlas of CD8 T cell dysfunctional states in cancer and infection. Mol Cell. 81(11):2477-2493.e10. Dikiy S, Li J, Bai L, Jiang M, Janke L, Zong X, Hao X, Hoyos B, Wang ZM, Xu B, Fan Y, Rudensky AY, Feng Y. (2021) A distal Foxp3 enhancer enables interleukin-2 dependent thymic Treg cell lineage commitment for robust immune tolerance. Immunity. 54(5):931-946.e11. Zeis P, Lian M, Fan X, Herman JS, Hernandez DC, Gentek R, Elias S, Symowski C, Knöpper K, Peltokangas N, Friedrich C, Doucet-Ladeveze R, Kabat AM, Locksley RM, Voehringer D, Bajenoff M, Rudensky AY, Romagnani C, Grün D, Gasteiger G. (2020) In Situ Maturation and Tissue Adaptation of Type 2 Innate Lymphoid Cell Progenitors. Immunity. 53(4):775-792.e9. Hemmers S, Schizas M, Rudensky AY. (2021) T reg cell-intrinsic requirements for ST2 signaling in health and neuroinflammation. J Exp Med. 218(2):e20201234. Michaels AJ, Campbell C, Bou-Puerto R, Rudensky AY. (2021) Nuclear receptor LXRβ controls fitness and functionality of activated T cells. J Exp Med.218(4):e20201311. Brown CC, Rudensky AY. (2021) Conceiving the Inconceivable: The Function of Aire in Immune Tolerance to Peripheral Tissue-Restricted Antigens in the Thymus. J Immunol. 206(2):245-247. Campbell C, Rudensky AY. (2021) Immunotherapy breaches low-sugar dieting of tumor Treg cells. Cell Metab. 33(5):851-852. Campbell C, Marchildon F, Michaels AJ, Takemoto N, van der Veeken J, Schizas M, Pritykin Y, Leslie CS, Intlekofer AM, Cohen P, Rudensky AY. (2020) FXR mediates T cell-intrinsic responses to reduced feeding during infection. Proc Natl Acad Sci U S A. 117(52):33446-33454. Wong HS, Park K, Gola A, Baptista AP, Miller CH, Deep D, Lou M, Boyd LF, Rudensky AY, Savage PA, Altan-Bonnet G, Tsang JS, Germain RN. (2021) A local regulatory T cell feedback circuit maintains immune homeostasis by pruning self-activated T cells. Cell. 184(15):3981-3997.e22. Niec RE, Rudensky AY, Fuchs E. (2021) Inflammatory adaptation in barrier tissues. Cell.184(13):3361-3375. Pritykin Y, van der Veeken J, Pine AR, Zhong Y, Sahin M, Mazutis L, Pe’er D, Rudensky AY, Leslie CS. (2021) A unified atlas of CD8 T cell dysfunctional states in cancer and infection. Mol Cell. 81(11):2477-2493.e10. Mendoza A, Yewdell WT, Hoyos B, Schizas M, Bou-Puerto R, Michaels AJ, Brown CC, Chaudhuri J, Rudensky AY. (2021) Assembly of a spatial circuit of T-bet-expressing T and B lymphocytes is required for antiviral humoral immunity. Sci Immunol. 6(60):eabi4710. van der Veeken J, Glasner A, Zhong Y, Hu W, Wang ZM, Bou-Puerto R, Charbonnier LM, Chatila TA, Leslie CS, Rudensky AY. (2020) The Transcription Factor Foxp3 Shapes Regulatory T Cell Identity by Tuning the Activity of trans-Acting Intermediaries. 53(5):971-984.e5. Ramsdell F, Rudensky AY. (2020) Foxp3: a genetic foundation for regulatory T cell differentiation and function. Nat Immunol. 21(7):708-709. Campbell C, McKenney PT, Konstantinovsky D, Isaeva OI, Schizas M, Verter J, Mai C, Jin WB, Guo CJ, Violante S, Ramos RJ, Cross JR, Kadaveru K, Hambor J, Rudensky AY. (2020) Bacterial metabolism of bile acids promotes generation of peripheral regulatory T cells. Nature. 581(7809):475-479. Brown CC, Gudjonson H, Pritykin Y, Deep D, Lavallée VP, Mendoza A, Fromme R, Mazutis L, Ariyan C, Leslie C, Pe’er D, Rudensky AY. (2019) Transcriptional Basis of Mouse and Human Dendritic Cell Heterogeneity. Cell. 179(4):846-863. Hemmers S, Schizas M, Azizi E, Dikiy S, Zhong Y, Feng Y, Altan-Bonnet G, Rudensky AY. (2019) IL-2 production by self-reactive CD4 thymocytes scales regulatory T cell generation in the thymus. J Exp Med. 216(11):2466-2478. van der Veeken J, Zhong Y, Sharma R, Mazutis L, Dao P, Pe’er D, Leslie CS, Rudensky AY. (2019) Natural Genetic Variation Reveals Key Features of Epigenetic and Transcriptional Memory in Virus-Specific CD8 T Cells. Immunity. 50(5):1202-1217. Konopacki C, Pritykin Y, Rubtsov Y, Leslie CS, Rudensky AY. (2019) Transcription factor Foxp1 regulates Foxp3 chromatin binding and coordinates regulatory T cell function. Nature immunology. 20(2):232. Fan X, Moltedo B, Mendoza A, Davydov AN, Faire MB, Mazutis L, Sharma R, Pe’er D, Chudakov DM, Rudensky AY. (2018) CD49b defines functionally mature Treg cells that survey skin and vascular tissues. J Exp Med. 215(11):2796-2814. Azizi E, Carr AJ, Plitas G, Cornish AE, Konopacki C, Prabhakaran S, Nainys J, Wu K, Kiseliovas V, Setty M, Choi K, Fromme RM, Dao P, McKenney PT, Wasti RC, Kadaveru K, Mazutis L, Rudensky AY, Pe’er. (2018) Single-Cell Map of Diverse Immune Phenotypes in the Breast Tumor Microenvironment. Cell. 174(5):1293-1308 Campbell C, Dikiy S, Bhattarai SK, Chinen T, Matheis F, Calafiore M, Hoyos B, Hanash A, Mucida D, Bucci V, Rudensky AY. (2018) Extrathymically Generated Regulatory T Cells Establish a Niche for Intestinal Border-Dwelling Bacteria and Affect Physiologic Metabolite Balance. Immunity. 48(6):1245-1257. Green JA, Arpaia N, Schizas M, Dobrin A, Rudensky AY. (2017) A nonimmune function of T cells in promoting lung tumor progression. JEM. 214(12):3565-3575. Levine AG, Mendoza A, Hemmers S, Moltedo B, Niec RE, Schizas M, Hoyos BE, Putintseva EV, Chaudhry A, Dikiy S, Fujisawa S, Chudakov DM, Treuting PM,Rudensky AY. (2017) Stability and function of regulatory T cells expressing the transcription factor T-bet. Nature. 546:421-425. Levine AG, Hemmers S, Baptista AP, Schizas M, Faire MB, Moltedo B, Konopacki C, Schmidt-Supprian M, Germain RN, Treuting PM, Rudensky AY. (2017) Suppression of lethal autoimmunity by regulatory T cells with a single TCR specificity. JEM. 214(3):609-622. Plitas G, Konopacki C, Wu K, Bos PD, Morrow M, Putintseva EV, Chudakov DM,Rudensky AY. (2016) Regulatory T Cells Exhibit Distinct Features in Human Breast Cancer. Immunity. 45:1122-1134. Chinen T, Kannan AK, Levine AG, Fan X, Klein U, Zheng Y, Gasteiger G, Feng Y, Fontenot JD, Rudensky AY. (2016) An essential role for the IL-2 receptor in Treg cell function. Nat Immunol. 17(11):1322-1333. van der Veeken J, Gonzalez AJ, Cho H, Arvey A, Hemmers S, Leslie CS, Rudensky AY. (2016) Memory of Inflammation in Regulatory T Cells. Cell.166:977-990. Arpaia N, Green J, Moltedo B, Arvey A, Hemmers S, Yuan S, Treuting P, Rudensky A. (2015) A Distinct Function of Regulatory T Cells in Tissue Protection. Cell. 162: 1078- 1089. Feng Y, van der Veeken J, Shugay M, Putintseva EV, Osmanbeyoglu HU, Dikiy S,Hoyos BE, Moltedo B, Hemmers S, Treuting P, Leslie CS, Chudakov DM, Rudensky AY. (2015) A mechanism for expansion of regulatory T-cell repertoire and its role in self-tolerance. Nature.528:132-136. Gasteiger G, Fan X, Dikiy S, Lee SY, Rudensky AY. (2015) Tissue residency of innate lymphoid cells in lymphoid and nonlymphoid organs. Science. 350:981-5. Feng Y, Arvey A, Chinen T, van der Veeken J, Gasteiger G, Rudensky AY. (2014) Control of the Inheritance of Regulatory T Cell Identity by a cis Element in the Foxp3 Locus. Cell. 158:749-63 Arpaia N, Campbell C, Fan X, Dikiy S, van der Veeken J, deRoos P, Liu H, Cross JR, Pfeffer K, Coffer PJ, Rudensky AY. (2013) Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation. Nature. 504:451-5. Reviews Campbell C, Rudensky A. (2019) Roles of Regulatory T Cells in Tissue Pathophysiology and Metabolism. Cell Metab. S1550-4131(19)30513-3. Elias S, Rudensky AY. (2019) Therapeutic use of regulatory T cells for graft-versus-host disease. Br J Haematol. 187(1):25-38. Plitas G, Rudensky AY. (2016) Regulatory T Cells: Differentiation and Function. Cancer Immunol Res. 4(9):721-5. Li MO, Rudensky AY. (2016) T cell receptor signalling in the control of regulatory T cell differentiation and function. Nat Rev Immunol. 16(4):220-33. Fan X, Rudensky AY. (2016) Hallmarks of Tissue-Resident Lymphocytes. Cell.164:1198-1211. Gasteiger G, Rudensky AY. (2014) Interactions between innate and adaptive lymphocytes. Nat Rev Immunol. 14(9):631-9. van der Veeken J, Arvey A, Rudensky A. (2013) Transcriptional control of regulatory T-cell differentiation. Cold Spring Harb Symp Quant Biol.78:215-22. Chaudhry A, Rudensky AY. (2013) Control of inflammation by integration of environmental cues by regulatory T cells. J Clin Invest. 123(3):939-44. Josefowicz SZ, Lu LF, Rudensky AY. (2012) Regulatory T cells: mechanisms of differentiation and function. Annu Rev Immunol. 30:531-64. Chinen T, Rudensky AY. (2012) The effects of commensal microbiota on immune cell subsets and inflammatory responses. Immunol Rev. 245(1):45-55. Rudensky AY. (2011) Regulatory T cells and Foxp3. Immunol Rev. 241(1):260-8. Littman DR, Rudensky AY. (2010) Th17 and regulatory T cells in mediating and restraining inflammation. Cell. 140(6):845-58. Josefowicz SZ, Rudensky A. (2009) Control of regulatory T cell lineage commitment and maintenance. Immunity. 30(5):616-25. Book traversal links for The Alexander Rudensky Lab Previous Featured News