Molecular Pharmacology Program
The Xinbo Yang Lab
Research
Assistant Professor
The Xinbo Yang lab is interested in studying the T cell receptor (TCR) specificity in cancer and autoimmune disease. The patrolling T cells constantly scan host tissues to eliminate infected or malignant cells. Failure to recognize such cells leads to pathogen evasion or cancer. Whereas mis-recognizing healthy tissue can cause collateral tissue damage that led to autoimmune disease. We seek to understand the molecular basis of this fine-tuned self-foreign discrimination system by applying interdisciplinary approaches such as, antigen-discovery platforms, protein engineering techniques and structural biology tools. The isolated antigens and their parent proteins for ‘orphan’ TCRs would then allow specific perturbation on each target to see how T cell responses are affected. Such mechanistic studies will facilitate animal model generation to further understand disease pathogenesis and ultimately benefit pMHC based therapeutic development.
People
Xinbo Yang, PhD
Assistant Professor
Assistant Professor
- Xinbo Yang’s lab applies structural biology and protein engineering to decode T cell receptor specificity in cancer and autoimmune disease.
- PhD, University of Maryland College Park
- [email protected]
- Email Address