Memorial Hospital Research Laboratories

The Simon Powell Lab

Simon N. Powell, MD, PhD

Professor

The major theme of our work is how DNA repair processes are disrupted in human cancers and how this can be exploited therapeutically.

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The Powell lab researches how normal cells become cancerous by studying how genome integrity is maintained.

Super-resolution microscopy of DNA end-resection at radiation-induced double-strand breaks.

Featured News

MSK Research Highlights, August 24, 2023

New MSK research suggests a method for revealing DNA repair “scars” could help make treatment decisions in BRCA1- and BRCA2-deficient cancers; modified a bacteria-made compound to target mutant KRAS-driven cancers; and shed new light on brain metastasis in non-small cell lung cancer.

At Work: Radiation Oncology Department Chair Simon Powell

Radiation oncologist Simon Powell eagerly tackles the challenge of translating discoveries from the laboratory to the clinic as effectively as possible.

Science Byte

Blue cells containing small red dots on a green and black background

Lifeguard on Duty: Looking at DNA Repair under a Microscope

Learn about what DNA repair looks like under a microscope.

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Publications Highlights

Ahmed-Seghir, S. et al. A local ATR-dependent checkpoint pathway is activated by a site-specific replication fork block in human cells. Elife 12, (2023)

Setton, J. et al. Long-molecule scars of backup DNA repair in BRCA1- and BRCA2-deficient cancers. Nature 621, 129–137 (2023)

Anand, R. et al. HELQ is a dual-function DSB repair enzyme modulated by RPA and RAD51. Nature 601, 268–273 (2022)

Moore, G. et al. Templated Insertions Are Associated Specifically with BRCA2 Deficiency and Overall Survival in Advanced Ovarian Cancer. Mol. Cancer Res. 20, 1061–1070 (2022)

Anand, R. et al. HELQ is a dual-function DSB repair enzyme modulated by RPA and RAD51. Nature 601, 268–273 (2022)

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People

Simon N. Powell, MD, PhD

Professor

Molecular biologist Simon Powell investigates DNA replication and recombination, chromosome dynamics, and human genetics.
PhD, MD, University of London

[email protected]: Email Address
View physician profile: Physician profile

Members

Erika Buechelmaier
Weill-Cornell Graduate Student

Joan Gomez-Aguilar

Research Technician

Atif Khan

Member

Robert Delsite, PhD — Robert Delsite
Senior Research Scientist

Simon Powell, MD, PhD — Simon Powell
Chairman Attending

Lab Alumni

Devi Annamalai

Research Fellow

Cristian Cleary

Research Technician

Nadeem Riaz

Resident

Samantha Sheppard

Research Fellow

Marcher Thompson

Graduate Research Assistant

Giana Bernheim

Research Technician

Ranjit Bindra

Resident

Alison Carley

Graduate Student

Jarin Chun

Research Fellow

Laura Eccles

Research Fellow

Alex Goglia

Research Technician

Benjamin Lok

Graduate Research Assistant

Robert Mutter

Resident

Ciara O'Driscoll

Research Fellow

Rohini Roy

Research Fellow

Lab Affiliations

Open Positions

To learn more about available postdoctoral opportunities, please visit our Career Center

To learn more about compensation and benefits for postdoctoral researchers at MSK, please visit Resources for Postdocs

Join the Powell Lab: Postdoctoral Opportunities in Cancer Biology at Memorial Sloan Kettering Cancer Center, NYC

The Powell Lab at Memorial Sloan Kettering Cancer Center is seeking enthusiastic postdoctoral scientists to lead multidisciplinary projects at the interface of DNA repair and translational cancer research.

Apply now

Get in Touch

[email protected]

Lab Head Email
646-888-3064

Lab Phone

Disclosures

Doctors and faculty members often work with pharmaceutical, device, biotechnology, and life sciences companies, and other organizations outside of MSK, to find safe and effective cancer treatments, to improve patient care, and to educate the health care community.

MSK requires doctors and faculty members to report (“disclose”) the relationships and financial interests they have with external entities. As a commitment to transparency with our community, we make that information available to the public.

Simon N. Powell discloses the following relationships and financial interests:

AstraZeneca
Professional Services and Activities
PharmaPier US LLC
Professional Services and Activities (Uncompensated)

Rain Therapeutics Inc.
Professional Services and Activities
Varian Medical Systems
Professional Services and Activities

The information published here is a complement to other publicly reported data and is for a specific annual disclosure period. There may be differences between information on this and other public sites as a result of different reporting periods and/or the various ways relationships and financial interests are categorized by organizations that publish such data.

This page and data include information for a specific MSK annual disclosure period (January 1, 2023 through disclosure submission in spring 2024). This data reflects interests that may or may not still exist. This data is updated annually.

Learn more about MSK’s COI policies here. For questions regarding MSK’s COI-related policies and procedures, email MSK’s Compliance Office at [email protected].

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