Prabha Sarangi

Education

B. Tech, Indian Institute of Technology; PhD Student, Weill Graduate School of Medical Sciences of Cornell University

Current Position
Senior Research Investigator, Biohaven

Publications

Clairmont CS, Sarangi P, Ponnienselvan K, Galli LD, Csete I, Moreau L, Adelmant G, Chowdhury D, Marto JA, D’Andrea AD (2020) TRIP13 regulates DNA repair pathway choice through REV7 conformational change. Nat Cell Biol. 22(1):87-96.

Sarangi P, Clairmont CS, D’Andrea AD (2020). Disassembly of the Shieldin Complex by TRIP13. Cell Cycle. 19(13):1565-1575. doi: 10.1080/15384101.2020.1758435. Epub 2020 May 18. Ceccaldi R, Sarangi P, D’Andrea AD (2016). The Fanconi anaemia pathway: new players and new functions. Nat Rev Mol Cell Biol. 17(6):337-49.

Sarangi P, Zhao X. SUMO-mediated regulation of DNA damage repair and responses.Trends Biochem Sci. 2015 Apr;40(4):233-42. doi: 10.1016/j.tibs.2015.02.006. Epub 2015 Mar 13. Review. PubMed PMID: 25778614; PubMed Central PMCID: PMC4380773.

Choi K, Batke S, Szakal B, Lowther J, Hao F, Sarangi P, Branzei D, Ulrich HD, Zhao X.Concerted and differential actions of two enzymatic domains underlie Rad5 contributions to DNA damage tolerance. Nucleic Acids Res. 2015 Mar 11;43(5):2666-77. doi: 10.1093/nar/gkv004. Epub 2015 Feb 17. PubMed PMID: 25690888; PubMed Central PMCID: PMC4357696.

Sarangi P, Steinacher R, Altmannova V, Fu Q, Paull TT, Krejci L, Whitby MC, Zhao X.Sumoylation influences DNA break repair partly by increasing the solubility of a conserved end resection protein. PLoS Genet. 2015 Jan;11(1):e1004899. doi: 10.1371/journal.pgen.1004899. eCollection 2015 Jan. PubMed PMID: 25569253; PubMed Central PMCID: PMC4287433.

Sarangi P, Altmannova V, Holland C, Bartosova Z, Hao F, Anrather D, Ammerer G, Lee SE, Krejci L, Zhao X. A versatile scaffold contributes to damage survival via sumoylation and nuclease interactions. Cell Rep. 2014 Oct 9;9(1):143-152. doi: 10.1016/j.celrep.2014.08.054. Epub 2014 Sep 25. PubMed PMID: 25263559; PubMed Central PMCID: PMC4280569.

Sarangi P, Bartosova Z, Altmannova V, Holland C, Chavdarova M, Lee SE, Krejci L, Zhao X. Sumoylation of the Rad1 nuclease promotes DNA repair and regulates its DNA association. Nucleic Acids Res. 2014 Jun;42(10):6393-404. doi: 10.1093/nar/gku300. Epub 2014 Apr 20. PubMed PMID: 24753409; PubMed Central PMCID: PMC4041466.

Vigasova D, Sarangi P, Kolesar P, Vlasáková D, Slezakova Z, Altmannova V, Nikulenkov F, Anrather D, Gith R, Zhao X, Chovanec M, Krejci L. Lif1 SUMOylation and its role in non-homologous end-joining. Nucleic Acids Res. 2013 May 1;41(10):5341-53. doi: 10.1093/nar/gkt236. Epub 2013 Apr 9. PubMed PMID: 23571759; PubMed Central PMCID: PMC3664818.

Cremona CA, Sarangi P, Zhao X. Sumoylation and the DNA damage response.Biomolecules. 2012 Sep;2(3):376-88. doi: 10.3390/biom2030376. eCollection 2012 Sep. Review. PubMed PMID: 24926426; PubMed Central PMCID: PMC4030838.

Kolesar P, Sarangi P, Altmannova V, Zhao X, Krejci L. Dual roles of the SUMO-interacting motif in the regulation of Srs2 sumoylation. Nucleic Acids Res. 2012 Sep;40(16):7831-43. doi: 10.1093/nar/gks484. Epub 2012 Jun 16. PubMed PMID: 22705796; PubMed Central PMCID: PMC3439891.