Molecular Biology Program

The Iestyn Whitehouse Lab

Research

Iestyn Whitehouse, PhD
Iestyn Whitehouse, PhD
Director of the Center for Epigenetics Research (CER)

Professor

The Whitehouse lab is broadly interested in understanding how chromatin functions in the regulation of cellular processes such as DNA replication, gene transcription and epigenetics. We focus on understanding basic mechanisms and use a combination of biochemical, molecular biological and genomics approaches. We like to develop new technology and are particularly interested in the development and application of single molecule technologies such as Nanopore sequencing and single molecule indexing strategies.

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Research Projects

Whitehouse Lab 2023

Publications Highlights

Balancing act of a leading strand DNA polymerase-specific domain and its exonuclease domain promotes genome-wide sister replication fork symmetry. Meng X, Claussin C, Regan-Mochrie G, Whitehouse I, Zhao X.Genes Dev. 2023 Jan 26. doi: 10.1101/gad.350054.122.PMID: 36702483

Single-molecule mapping of replisome progression. Claussin C, Vazquez J, Whitehouse I.Mol Cell. 2022 Apr 7;82(7):1372-1382.e4. doi: 10.1016/j.molcel.2022.02.010. Epub 2022 Mar 2.PMID: 35240057

DNA replication through a chromatin environment. Bellush JM, Whitehouse I.Philos Trans R Soc Lond B Biol Sci. 2017 Oct 5;372(1731):20160287. doi: 10.1098/rstb.2016.0287.PMID: 28847824

DNA-mediated association of two histone-bound complexes of yeast Chromatin Assembly Factor-1 (CAF-1) drives tetrasome assembly in the wake of DNAreplication. Mattiroli F, Gu Y, Yadav T, Balsbaugh JL, Harris MR, Findlay ES, Liu Y, Radebaugh CA, Stargell LA, Ahn NG, Whitehouse I, Luger K.Elife. 2017 Mar 18;6:e22799. doi: 10.7554/eLife.22799.PMID: 28315523

Spatiotemporal coupling and decoupling of gene transcription with DNAreplication origins during embryogenesis in C. elegans. Pourkarimi E, Bellush JM, Whitehouse I.Elife. 2016 Dec 23;5:e21728. doi: 10.7554/eLife.21728.PMID: 28009254

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People

Iestyn Whitehouse, PhD

Iestyn Whitehouse, PhD

Director of the Center for Epigenetics Research (CER)

Professor

  • Molecular biologist Iestyn Whitehouse investigates chromatin structure and the function of ATP-dependent chromatin remodelling enzymes.
  • PhD, The University of Dundee
[email protected]
Email Address
212-639-8398
Office Phone

Members

Clémence Claussin
Clémence Claussin

Sr. Research Scientist

Axel Delamarre
Axel Delamarre

Sr. Research Scientist

Rebecca MacLean

SKI Administrative Assistant II

Maurane Reveil
Maurane Reveil

Research Scholar

Lab Alumni
Lisbelle Adorno

Administrative Assistant

Jennifer Yavid
Jennifer A Yavid

Research Technician

Jieqing (Jenny) Jiang

Graduate Student

Nickolas Almodovar

Graduate Student

Sean McGuffee

Postdoctoral Fellow

Nicolas Nocetti

Graduate Student

Duncan Smith

Postdoctoral Fellow

Tejas Yadav

Graduate Student

James Bellush
James Bellush

Graduate Student

Jessica Fyodorova
Jessica Fyodorova

Research Technician

Ehsan Pourkarimi
Ehsan Pourkarimi

Postdoctoral Fellow

Lab Affiliations

Open Positions

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Get in Touch

Disclosures

Doctors and faculty members often work with pharmaceutical, device, biotechnology, and life sciences companies, and other organizations outside of MSK, to find safe and effective cancer treatments, to improve patient care, and to educate the health care community.

MSK requires doctors and faculty members to report (“disclose”) the relationships and financial interests they have with external entities. As a commitment to transparency with our community, we make that information available to the public.

Iestyn Whitehouse discloses the following relationships and financial interests:

No disclosures meeting criteria for time period


The information published here is a complement to other publicly reported data and is for a specific annual disclosure period. There may be differences between information on this and other public sites as a result of different reporting periods and/or the various ways relationships and financial interests are categorized by organizations that publish such data.


This page and data include information for a specific MSK annual disclosure period (January 1, 2023 through disclosure submission in spring 2024). This data reflects interests that may or may not still exist. This data is updated annually.

Learn more about MSK’s COI policies here. For questions regarding MSK’s COI-related policies and procedures, email MSK’s Compliance Office at [email protected].


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