Molecular Biology Program
The Iestyn Whitehouse Lab
Research
![Iestyn Whitehouse, PhD](https://www.sloankettering.edu/sites/default/files/styles/width_200_1x1/public/node/4405/person/whitehouse-lestyn_180511_07_1200x800.jpg?h=10d202d3)
Professor
The Whitehouse lab is broadly interested in understanding how chromatin functions in the regulation of cellular processes such as DNA replication, gene transcription and epigenetics. We focus on understanding basic mechanisms and use a combination of biochemical, molecular biological and genomics approaches. We like to develop new technology and are particularly interested in the development and application of single molecule technologies such as Nanopore sequencing and single molecule indexing strategies.
Research Projects
![Whitehouse Lab 2023](https://www.sloankettering.edu/sites/default/files/node/4405/images/whitehouse-lab-230620-004_rt_1200x800.jpg)
Featured News
![Molecular Biologist Iestyn Whitehouse](https://www.sloankettering.edu/sites/default/files/styles/width_200/public/node/4735/image/447033.jpg)
![Recipients of the Louis V. Gerstner, Jr. Young Investigators Fund, pictured with Mr. Gerstner. (From left) Iestyn Whitehouse, Hans-Guido Wendel, Mr. Gerstner, Stephen Long, and Timothy Chan.](https://www.sloankettering.edu/sites/default/files/styles/width_200/public/node/4911/image/459717.jpg)
Publications Highlights
Balancing act of a leading strand DNA polymerase-specific domain and its exonuclease domain promotes genome-wide sister replication fork symmetry. Meng X, Claussin C, Regan-Mochrie G, Whitehouse I, Zhao X.Genes Dev. 2023 Jan 26. doi: 10.1101/gad.350054.122.PMID: 36702483
Single-molecule mapping of replisome progression. Claussin C, Vazquez J, Whitehouse I.Mol Cell. 2022 Apr 7;82(7):1372-1382.e4. doi: 10.1016/j.molcel.2022.02.010. Epub 2022 Mar 2.PMID: 35240057
DNA replication through a chromatin environment. Bellush JM, Whitehouse I.Philos Trans R Soc Lond B Biol Sci. 2017 Oct 5;372(1731):20160287. doi: 10.1098/rstb.2016.0287.PMID: 28847824
DNA-mediated association of two histone-bound complexes of yeast Chromatin Assembly Factor-1 (CAF-1) drives tetrasome assembly in the wake of DNAreplication. Mattiroli F, Gu Y, Yadav T, Balsbaugh JL, Harris MR, Findlay ES, Liu Y, Radebaugh CA, Stargell LA, Ahn NG, Whitehouse I, Luger K.Elife. 2017 Mar 18;6:e22799. doi: 10.7554/eLife.22799.PMID: 28315523
Spatiotemporal coupling and decoupling of gene transcription with DNAreplication origins during embryogenesis in C. elegans. Pourkarimi E, Bellush JM, Whitehouse I.Elife. 2016 Dec 23;5:e21728. doi: 10.7554/eLife.21728.PMID: 28009254
People
![Iestyn Whitehouse, PhD](https://www.sloankettering.edu/sites/default/files/styles/width_200_1x1/public/node/4405/person/whitehouse-lestyn_180511_07_1200x800.jpg?h=10d202d3)
Iestyn Whitehouse, PhD
Director of the Center for Epigenetics Research (CER)
Professor
- Molecular biologist Iestyn Whitehouse investigates chromatin structure and the function of ATP-dependent chromatin remodelling enzymes.
- PhD, The University of Dundee
- [email protected]
- Email Address
- 212-639-8398
- Office Phone
Members
![Clémence Claussin](https://www.sloankettering.edu/sites/default/files/styles/width_200_1x1/public/node/155788/3x2/claussin-clemence_180511_09_1200x800.jpg?h=10d202d3)
![Axel Delamarre](https://www.sloankettering.edu/sites/default/files/styles/width_200_1x1/public/node/155791/main_image/axel-delamarre_2023jpg.jpg)
![Benton Bailey](https://www.sloankettering.edu/sites/default/files/styles/width_200_1x1/public/node/276371/main_image/bailey-benton-230620-002_rt_1200x1200.jpg)
![](https://www.sloankettering.edu/sites/default/files/styles/width_200_1x1/public/node/291251/main_image/img-20230416-wa0006.jpg?h=44459bcb)
![Maurane Reveil](https://www.sloankettering.edu/sites/default/files/styles/width_200_1x1/public/node/276376/main_image/reveil-maurane-230620-003_rt_1200x1200.jpg)
![](https://www.sloankettering.edu/sites/default/files/styles/width_200_1x1/public/node/291266/main_image/tiffanywillis_headshot.jpg?h=54ede290)
![Clémence Claussin](https://www.sloankettering.edu/sites/default/files/styles/width_200_1x1/public/node/155788/3x2/claussin-clemence_180511_09_1200x800.jpg?h=10d202d3)
Sr. Research Scientist
![Axel Delamarre](https://www.sloankettering.edu/sites/default/files/styles/width_200_1x1/public/node/155791/main_image/axel-delamarre_2023jpg.jpg)
Sr. Research Scientist
![Benton Bailey](https://www.sloankettering.edu/sites/default/files/styles/width_200_1x1/public/node/276371/main_image/bailey-benton-230620-002_rt_1200x1200.jpg)
Research Technician
![](https://www.sloankettering.edu/sites/default/files/styles/width_200_1x1/public/node/291251/main_image/img-20230416-wa0006.jpg?h=44459bcb)
SKI Administrative Assistant II
![Maurane Reveil](https://www.sloankettering.edu/sites/default/files/styles/width_200_1x1/public/node/276376/main_image/reveil-maurane-230620-003_rt_1200x1200.jpg)
Research Scholar
![](https://www.sloankettering.edu/sites/default/files/styles/width_200_1x1/public/node/291266/main_image/tiffanywillis_headshot.jpg?h=54ede290)
Research Technician
![Jennifer Yavid](https://www.sloankettering.edu/sites/default/files/styles/width_200_1x1/public/node/238408/main_image/yavid-jennifer-230620-008_rt_1200x1200.jpg?h=cd2a7045)
![Jessica Fyodorova](https://www.sloankettering.edu/sites/default/files/styles/width_200_1x1/public/node/155794/3x2/fyodorova-jessica_180511_12_1200x800.jpg?h=10d202d3)
![Ehsan Pourkarimi](https://www.sloankettering.edu/sites/default/files/styles/width_200_1x1/public/node/155785/3x2/pourkarimi-daryakenari-ehsan_180511_12_1200x800.jpg?h=10d202d3)
Lab Alumni
Administrative Assistant
![Jennifer Yavid](https://www.sloankettering.edu/sites/default/files/styles/width_200_1x1/public/node/238408/main_image/yavid-jennifer-230620-008_rt_1200x1200.jpg?h=cd2a7045)
Research Technician
Graduate Student
Graduate Student
Postdoctoral Fellow
Graduate Student
Postdoctoral Fellow
Graduate Student
![James Bellush](https://www.sloankettering.edu/sites/default/files/styles/width_200_1x1/public/node/25427/3x2/bellush-james_180511_06_1200x800.jpg?h=10d202d3)
Graduate Student
![Jessica Fyodorova](https://www.sloankettering.edu/sites/default/files/styles/width_200_1x1/public/node/155794/3x2/fyodorova-jessica_180511_12_1200x800.jpg?h=10d202d3)
Research Technician
![Ehsan Pourkarimi](https://www.sloankettering.edu/sites/default/files/styles/width_200_1x1/public/node/155785/3x2/pourkarimi-daryakenari-ehsan_180511_12_1200x800.jpg?h=10d202d3)
Postdoctoral Fellow
Open Positions
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Get in Touch
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Disclosures
Doctors and faculty members often work with pharmaceutical, device, biotechnology, and life sciences companies, and other organizations outside of MSK, to find safe and effective cancer treatments, to improve patient care, and to educate the health care community.
MSK requires doctors and faculty members to report (“disclose”) the relationships and financial interests they have with external entities. As a commitment to transparency with our community, we make that information available to the public.
Iestyn Whitehouse discloses the following relationships and financial interests:
No disclosures meeting criteria for time period
The information published here is for a specific annual disclosure period. There may be differences between information on this and other public sites as a result of different reporting periods and/or the various ways relationships and financial interests are categorized by organizations that publish such data.
This page and data include information for a specific MSK annual disclosure period (January 1, 2023 through disclosure submission in spring 2024). This data reflects interests that may or may not still exist. This data is updated annually.
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