Structural Biology Program

The Dimitar Nikolov Lab

Dimitar B. Nikolov, PhD

Professor

Research in our laboratory aims to characterize the molecular mechanisms underlying cell-to-cell interactions and signal transduction across the cell membrane. We are particularly interested in understanding how receptors located on the surface of developing axons and neurons interact with extracellular ligands to guide the development of the nervous system and the wiring of the brain.

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Publications Highlights

Xu K, Wu Z, Renier N, Antipenko A, Tzvetkova-Robev D, Xu Y, Minchenko M, Nardi-Dei V, Rajashankar KR, Himanen J, Tessier-Lavigne M, Nikolov DB., Structures of netrin-1 bound to two receptors provide insight into its axon guidance mechanism., Science. (2014), May 29, pii: 1255149. [Epub ahead of print]

Barton WA, Dalton AC, Seegar TC, Himanen JP, and Nikolov DB, Tie2 and Eph Receptor Tyrosine Kinase Activation and Signaling, Cold Spring Harbor Perspectives in Biology: “Signaling by Receptor Tyrosine Kinases” edited by Joseph Schlessinger and Mark A. Lemmon, Cold Spring Harbor Laboratory Press, ISBN978-1-936113-33-0, pages 287-303, (2014).

Xu K, Tzvetkova-Robev D, Xu Y, Goldgur Y, Chan YP, Himanen JP, Nikolov DB., Insights into Eph receptor tyrosine kinase activation from crystal structures of the EphA4 ectodomain and its complex with ephrin-A5. Proc Natl Acad Sci U S A. 110(36):14634-9, (2013).

Yu X, Seegar TC, Dalton AC, Tzvetkova-Robev D, Goldgur Y, Rajashankar KR, Nikolov DB, Barton WA, Structural basis for angiopoietin-1-mediated signaling initiation. Proc Natl Acad Sci U S A.; 110(18):7205-10, (2013).

P.W. Janes, N. Saha, W.A. Barton, M.V. Kolev, S.H. Wimmer-Kleikamp, E. Nievergall, C.P. Blobel, J-P. Himanen, M. Lackmann, and D.B. Nikolov, Adam Meets Eph: An ADAM Substrate Recognition Module Acts as a Molecular Switch for Ephrin Cleavage In trans. Cell 123(2): 291-304, (2005).

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People

Dimitar B. Nikolov, PhD

Professor

The Nikolov laboratory focuses on the structural, biophysical, and biochemical characterization of the molecular mechanisms of cell-cell interactions and signal transduction in the nervous system.
PhD, The Rockefeller University

[email protected]: Email Address
212-639-6784: Office Phone

Members

Dimitar B. Nikolov, PhD — Dimitar B. Nikolov
Member

Juha Himanen, PhD — Juha Himanen
Senior Research Scientist

Alexander Antipenko, PhD — Alexander Antipenko
Senior Research Scientist

Nayanendu Saha

Senior Research Scientist

Momchil Kolev, MS — Momchil Kolev
Research Assistant

Dorothea Robev, MS — Dorothea Robev
Research Assistant and Laboratory Manager

Lab Alumni

Emilia Mason, PhD — Emilia Mason
Postdoctoral Research Scholar

Lab Affiliations

Open Positions

To learn more about available postdoctoral opportunities, please visit our Career Center

To learn more about compensation and benefits for postdoctoral researchers at MSK, please visit Resources for Postdocs

Get in Touch

[email protected]

Lab Head Email
212-639-6784

Office Phone
212-639-6837 / 6806

Lab Phone
212-717-3135

Lab Fax

Disclosures

Doctors and faculty members often work with pharmaceutical, device, biotechnology, and life sciences companies, and other organizations outside of MSK, to find safe and effective cancer treatments, to improve patient care, and to educate the health care community.

MSK requires doctors and faculty members to report (“disclose”) the relationships and financial interests they have with external entities. As a commitment to transparency with our community, we make that information available to the public.

Dimitar B. Nikolov discloses the following relationships and financial interests:

No disclosures meeting criteria for time period

The information published here is a complement to other publicly reported data and is for a specific annual disclosure period. There may be differences between information on this and other public sites as a result of different reporting periods and/or the various ways relationships and financial interests are categorized by organizations that publish such data.

This page and data include information for a specific MSK annual disclosure period (January 1, 2023 through disclosure submission in spring 2024). This data reflects interests that may or may not still exist. This data is updated annually.

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