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An illustration of a beta-amyloid plaque among the neurons in a brain.
MSK Study Links Inflammation to Alzheimer’s Disease Development

An enzyme that contributes to plaque formation in the brain also serves as a first line of defense against bacteria and viruses, suggesting a link between the two.
MSK molecular geneticist Elli Papaemmanouil
Large International Study Pinpoints Impact of TP53 Gene Mutations on Blood Cancer Severity

Having two mutated copies of the TP53 gene — as opposed to a single mutated copy — is associated with worse outcomes in a blood cancer called myelodysplastic syndrome, according to a new study led by researchers at Memorial Sloan Kettering.
Corina Amor Vegas
2020 GSK Chairman’s Prize Recognizes Research Exploring New Immunotherapy Approach for Age-Related Inflammatory Diseases

Meet Corina Amor Vegas, a fourth-year student in the Gerstner Sloan Kettering Graduate School of Biomedical Sciences (GSK), who has been awarded the 2020 Chairman’s Prize.
Finding
Section of a lung cancer tumor in mice
A Never-Before-Seen Cell State May Explain Cancer’s Ability to Resist Drugs

Identified in mice, this unusual cell state emerges early during tumor evolution and gives tumors enormous malleability.
Charles Sawyers in his lab
A New Approach in Prostate Cancer: Targeting the Cells Surrounding the Tumor

Scientists have found a protein that empowers prostate tumors to resist hormone therapy.
MSK physician-scientists Michael Glickman and Gil Redelman-Sidi
The ABCs of BCG: Oldest Approved Immunotherapy Gets New Explanation

BCG has been used to treat bladder cancer for more than 30 years. Scientists are still learning how it works.
In the Lab
An illustration of sugar being sprinkled on a cancer cell.
Just Add Sugar: How a Protein’s Small Change Leads to Big Trouble for Cells

A study from investigators in the Sloan Kettering Institute uncovers the details of how a key protein called GRP94 becomes disrupted, leading to cancer and other diseases.
In the Lab
Confocal microscopy image of a female fruit fly brain.
How Fruit Flies Know When They've Mated

Research from investigators at the Sloan Kettering Institute shows how a brain circuit controls mating behavior in fruit flies.
In the Lab
CT scan showing lymphoma in the abdomen between the liver and the gallbladder.
A Metabolic Enzyme Drives Lymphoma and Is a Potential Drug Target

New research from Sloan Kettering Institute investigators pinpoints altered cell metabolism as a cause of B cell lymphoma.
In the Lab
Fluorescent image of CAR T cells in mouse liver fibrosis
A New Target for CAR T Cells: Senescence-Related Diseases

From atherosclerosis and diabetes to liver fibrosis and osteoarthritis, senescent cells are at the root of many debilitating diseases. Scientists increasingly have them in the crosshairs.